This sign prohibits access to vehicles intended for the transport of goods, meaning...

A)trucks, exclusively.
B)trucks and vans depending on their mass.
C)trucks and vans regardless of their mass.Correct
The sign in the question prohibits entry, on the road where it is placed, to vehicles intended for the transport of goods, trucks and vans, regardless of their maximum authorized mass.
They may not pass even if the vehicle is empty.
Do not confuse with the sign that prohibits access depending on the maximum authorized mass.